Influence of MDM2 polymorphisms on squamous cell carcinoma susceptibility: a meta-analysis

• Main Authors: Yu H, Li H, Zhang J, Liu G
• Format: Article
• Language: English
• Published: Dove Medical Press 2016-10-01
• Series: OncoTargets and Therapy
• Subjects: MDM2; polymorphism; SCC; ESCC; meta-analysis; susceptibility
• Online Access: https://www.dovepress.com/influence-of-mdm2-polymorphisms-on-squamous-cell-carcinoma-susceptibil-peer-reviewed-article-OTT

Huanxin Yu, Haiyan Li, Jinling Zhang, Gang Liu Department of Otorhinolaryngology Head and Neck Surgery, Tianjin Huanhu Hospital, Tianjin, People’s Republic of China Purpose: Controversial associations between single-nucleotide polymorphisms (rs2279744, rs937283, rs3730485) of the MDM2 gene and the etiology of squamous cell carcinomas (SCCs) have been reported. This merits further comprehensive assessment.Materials and methods: We systematically reviewed the available data and conducted an updated meta-analysis to evaluate the genetic effect of MDM2 polymorphisms in SCC susceptibility, using Stata/SE 12.0 software.Results: After screening, 7,987 SCC cases and 12,954 controls from 26 eligible case–control studies were enrolled. Overall, compared with the control group, a significantly increased SCC risk was observed for the MDM2 rs2279744 polymorphism in the Asian population (test of association: odds ratio [OR] 1.12, P=0.027 for G vs T; OR 1.26, P=0.016 for GG vs TT; OR 1.25, P<0.001 for GG vs TT + TG; and OR 1.08, P=0.023 for carrier G vs T). In subgroup analysis by SCC type, a similarly increased esophageal SCC risk was detected (OR 1.19, P<0.001 for G vs T; OR 1.46, P<0.001 for GG vs TT; and OR 1.48, P=0.005 for GG vs TT + TG). Furthermore, MDM2–TP53 double mutation was statistically associated with increased SCC susceptibility overall (OR 1.52, P=0.001), especially in the Asian population (OR 1.49, P=0.022). However, no significant difference between the control and case groups was obtained for MDM2 rs937283 or rs3730485 under any genetic model (all P>0.05).Conclusion: Our results highlight a positive association between the GG genotype of MDM2 rs2279744 polymorphism and an increased risk of esophageal SCC in the Asian population, which needs to be clarified by more large-scale studies. Keywords: MDM2, SCC, SNP, meta-analysis