Necrosulfonamide Ameliorates Neurological Impairment in Spinal Cord Injury by Improving Antioxidative Capacity

Necrosulfonamide Ameliorates Neurological Impairment in Spinal Cord Injury by Improving Antioxidative Capacity

Currently, there is no efficient therapy for spinal cord injury (SCI). Anoxemia after SCI is a key problem, which leads to tissue destruction, while hypoxia after SCI induces cell injury along with inflammation. Mixed-lineage kinase domain-like protein (MLKL) is a critical signal molecule of necropt...

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Bibliographic Details
Main Authors: Jianhang Jiao, Yang Wang, Pengfei Ren, Shicai Sun, Minfei Wu
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Pharmacology
Subjects:
spinal cord injury
necrosulfonamide
mixed-lineage kinase domain-like protein activation
neurological impairment
antioxidative capacity
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.01538/full

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