Successful treatment of <it>Candida parapsilosis </it>mural endocarditis with combined caspofungin and voriconazole

• Main Authors: de Juan-Romero Miguel, de la Torre-Fernández María J, Sanz-Rodríguez César, León Cristóbal, Castro-Orjales María J, López-Ciudad Víctor, Collell-Llach María D, Díaz-López María D
• Format: Article
• Language: English
• Published: BMC 2006-04-01
• Series: BMC Infectious Diseases
• Online Access: http://www.biomedcentral.com/1471-2334/6/73
• ISSN: 1471-2334

<p>Abstract</p> <p>Background</p> <p>Fungal mural endocarditis is a rare entity in which the antemortem diagnosis is seldom made. Seven cases of mural endocarditis caused by <it>Candida </it>spp. have been collected from literature and six of these patients died after treatment with amphotericin B.</p> <p>Case presentation</p> <p>We report a case of mural endocarditis diagnosed by transesophageal echocardiogram and positive blood cultures to <it>Candida parapsilosis</it>. Because blood cultures continued to yield <it>C. parapsilosis </it>despite caspofungin monotherapy, treatment with voriconazole was added.</p> <p>Conclusion</p> <p>This is the first description of successful treatment of <it>C. parapsilosis </it>mural endocarditis with caspofungin and voriconazole.</p>