The Non-Essential Amino Acid Cysteine Becomes Essential for Tumor Proliferation and Survival

The non-essential amino acid cysteine is used within cells for multiple processes that rely on the chemistry of its thiol group. Under physiological conditions, many non-transformed tissues rely on glutathione, circulating cysteine, and the de novo cysteine synthesis (transsulfuration) pathway as so...

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Bibliographic Details
Main Authors: Joseph A. Combs, Gina M. DeNicola
Format: Article
Language:English
Published: MDPI AG 2019-05-01
Series:Cancers
Subjects:
xCT
CBS
CSE
GGT
Online Access:https://www.mdpi.com/2072-6694/11/5/678