Effects of lipopolysaccharide on low- and high-density cultured rabbit vascular smooth muscle cells: differential modulation of nitric oxide release, ERK1/ERK2 MAP kinase activity, protein tyrosine phosphatase activity, and DNA synthesis

Effects of lipopolysaccharide on low- and high-density cultured rabbit vascular smooth muscle cells: differential modulation of nitric oxide release, ERK1/ERK2 MAP kinase activity, protein tyrosine phosphatase activity, and DNA synthesis

Previous studies have shown that exogenously generated nitric oxide (NO) inhibits smooth muscle cell proliferation. In the present study, we stimulated rabbit vascular smooth muscle cells (RVSMC) with E. coli lipopolysaccharide (LPS), a known inducer of NO synthase transcription, and established a c...

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Bibliographic Details
Main Authors: L.C. Barbosa de Oliveira, C.J. Rocha Oliveira, D.M. Fries, A. Stern, H.P. Monteiro
Format: Article
Language:English
Published: Associação Brasileira de Divulgação Científica 2002-02-01
Series:Brazilian Journal of Medical and Biological Research
Subjects:
Nitric oxide
Lipopolysaccharide
Protein tyrosine phosphatases
Mitogen-activated protein kinases
DNA synthesis
Cell density
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002000200006

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