Stimulator of Interferon Genes in Classical Dendritic Cells Controls Mucosal Th17 Responses to Cyclic Dinucleotides for Host Defenses Against Microbial Infections in Gut

Stimulator of Interferon Genes in Classical Dendritic Cells Controls Mucosal Th17 Responses to Cyclic Dinucleotides for Host Defenses Against Microbial Infections in Gut

Cyclic dinucleotides are bacterial signal transducers that bind to host intracellular protein, stimulator of interferon genes (STING) encoded by Tmem173. In this study, we demonstrate that STING triggers adaptive immune responses that control Th17 differentiation. Cyclic dinucleotides recognition en...

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Bibliographic Details
Main Authors: Song Liu, Qiuyuan Xia, Xiuwen Wu, Feng Sun, Qiongyuan Hu, Jie Wu, Meng Wang, Qiu Rao, Wenxian Guan
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-05-01
Series:Frontiers in Immunology
Subjects:
stimulator of interferon genes
dendritic cell
Th17
Salmonella
cyclic dinucleotides
Crohn’s disease
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.01085/full

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