TRIB2 functions as novel oncogene in colorectal cancer by blocking cellular senescence through AP4/p21 signaling

TRIB2 functions as novel oncogene in colorectal cancer by blocking cellular senescence through AP4/p21 signaling

Abstract Background Cellular senescence is a state of irreversible cell growth arrest and senescence cells permanently lose proliferation potential. Induction of cellular senescence might be a novel therapy for cancer cells. TRIB2 has been reported to participate in regulating proliferation and drug...

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Bibliographic Details
Main Authors: Zhenlin Hou, Kaixuan Guo, Xuling Sun, Fuqing Hu, Qianzhi Chen, Xuelai Luo, Guihua Wang, Junbo Hu, Li Sun
Format: Article
Language:English
Published: BMC 2018-12-01
Series:Molecular Cancer
Subjects:
Colorectal cancer
Cellular senescence
TRIB2
AP4
p53
p21
Online Access:http://link.springer.com/article/10.1186/s12943-018-0922-x

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