Sequencing of E2 and NS5A regions of HCV genotype 3a in Brazilian patients with chronic hepatitis

Sequencing of E2 and NS5A regions of HCV genotype 3a in Brazilian patients with chronic hepatitis

Hepatitis C virus (HCV) is a major cause of liver disease throughout the world. The NS5A and E2 proteins of HCV genotype 1 were reported to inhibit the double-stranded (ds) RNA-dependent protein kinase (PKR), which is involved in the cellular antiviral response induced by interferon (IFN). The respo...

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Bibliographic Details
Main Authors: Fernanda de Mello Malta, José Eymard Moraes de Medeiros-Filho, Raymundo Soares de Azevedo, Luzia Gonçalves, Luiz Caetano da Silva, Flair José Carrilho, João Renato Rebello Pinho
Format: Article
Language:English
Published: Instituto Oswaldo Cruz, Ministério da Saúde 2010-02-01
Series:Memórias do Instituto Oswaldo Cruz.
Subjects:
E2 protein
hepatitis C virus
interferon sensitivity determining region
NS5A protein
PKR-eIF2a phosphorylation homology domain
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762010000100014

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762010000100014

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