CREB depletion in smooth muscle cells promotes medial thickening, adventitial fibrosis and elicits pulmonary hypertension

Levels of the cAMP-responsive transcription factor, CREB, are reduced in medial smooth muscle cells in remodeled pulmonary arteries from hypertensive calves and rats with chronic hypoxia-induced pulmonary hypertension. Here, we show that chronic hypoxia fails to promote CREB depletion in pulmonary a...

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Bibliographic Details
Main Authors: Chrystelle V. Garat, Susan M. Majka, Timothy M. Sullivan, Joseph T. Crossno, Jane E.B. Reusch, Dwight J. Klemm
Format: Article
Language:English
Published: SAGE Publishing 2020-04-01
Series:Pulmonary Circulation
Online Access:https://doi.org/10.1177/2045894019898374

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