Case Report: Molecular Features and Treatment Options for Small Bowel Adenocarcinoma

Small bowel adenocarcinoma (SBA) is a rare malignancy characterized by poor prognosis. Recent efforts have sought to elucidate the genetic landscape and the molecular drivers behind this disease. Herein, we report the main molecular alterations in two metastatic (stage IV) SBA patients. Interestingl...

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Main Authors:	Miguel Cordova-Delgado, Gonzalo Pizarro, Mauricio P. Pinto, Maria Elisa Herrera, Marcelo Garrido
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2021-03-01
Series:	Frontiers in Oncology
Subjects:	case report small bowel adenocarcinoma comprehensive genomic profiling precision oncology therapeutic options
Online Access:	https://www.frontiersin.org/articles/10.3389/fonc.2021.593561/full

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spelling	doaj-c77b8b5d8af64b77a339097d38201e4a2021-03-10T05:08:43ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2021-03-011110.3389/fonc.2021.593561593561Case Report: Molecular Features and Treatment Options for Small Bowel AdenocarcinomaMiguel Cordova-Delgado0Miguel Cordova-Delgado1Gonzalo Pizarro2Mauricio P. Pinto3Maria Elisa Herrera4Maria Elisa Herrera5Marcelo Garrido6Hematology and Oncology Department, Faculty of Medicine, Pontificia Universidad Católica de Chile (PUC), Santiago, ChileFaculty of Chemical and Pharmaceutical Sciences, Universidad de Chile, Santiago, ChileHematology and Oncology Department, Faculty of Medicine, Pontificia Universidad Católica de Chile (PUC), Santiago, ChileHematology and Oncology Department, Faculty of Medicine, Pontificia Universidad Católica de Chile (PUC), Santiago, ChileMedical Oncology Department, Hospital de Valdivia, Valdivia, ChileMedical Oncology Department, Clínica Alemana de Valdivia, Valdivia, ChileHematology and Oncology Department, Faculty of Medicine, Pontificia Universidad Católica de Chile (PUC), Santiago, ChileSmall bowel adenocarcinoma (SBA) is a rare malignancy characterized by poor prognosis. Recent efforts have sought to elucidate the genetic landscape and the molecular drivers behind this disease. Herein, we report the main molecular alterations in two metastatic (stage IV) SBA patients. Interestingly, one of them had gene alterations that affected signaling pathways previously described for SBA. However, a second patient displayed previously unreported alterations in this particular tumor type. Based on these findings we discuss potential treatment options for patients affected by this rare, aggressive disease.https://www.frontiersin.org/articles/10.3389/fonc.2021.593561/fullcase reportsmall bowel adenocarcinomacomprehensive genomic profilingprecision oncologytherapeutic options
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Miguel Cordova-Delgado Miguel Cordova-Delgado Gonzalo Pizarro Mauricio P. Pinto Maria Elisa Herrera Maria Elisa Herrera Marcelo Garrido
spellingShingle	Miguel Cordova-Delgado Miguel Cordova-Delgado Gonzalo Pizarro Mauricio P. Pinto Maria Elisa Herrera Maria Elisa Herrera Marcelo Garrido Case Report: Molecular Features and Treatment Options for Small Bowel Adenocarcinoma Frontiers in Oncology case report small bowel adenocarcinoma comprehensive genomic profiling precision oncology therapeutic options
author_facet	Miguel Cordova-Delgado Miguel Cordova-Delgado Gonzalo Pizarro Mauricio P. Pinto Maria Elisa Herrera Maria Elisa Herrera Marcelo Garrido
author_sort	Miguel Cordova-Delgado
title	Case Report: Molecular Features and Treatment Options for Small Bowel Adenocarcinoma
title_short	Case Report: Molecular Features and Treatment Options for Small Bowel Adenocarcinoma
title_full	Case Report: Molecular Features and Treatment Options for Small Bowel Adenocarcinoma
title_fullStr	Case Report: Molecular Features and Treatment Options for Small Bowel Adenocarcinoma
title_full_unstemmed	Case Report: Molecular Features and Treatment Options for Small Bowel Adenocarcinoma
title_sort	case report: molecular features and treatment options for small bowel adenocarcinoma
publisher	Frontiers Media S.A.
series	Frontiers in Oncology
issn	2234-943X
publishDate	2021-03-01
description	Small bowel adenocarcinoma (SBA) is a rare malignancy characterized by poor prognosis. Recent efforts have sought to elucidate the genetic landscape and the molecular drivers behind this disease. Herein, we report the main molecular alterations in two metastatic (stage IV) SBA patients. Interestingly, one of them had gene alterations that affected signaling pathways previously described for SBA. However, a second patient displayed previously unreported alterations in this particular tumor type. Based on these findings we discuss potential treatment options for patients affected by this rare, aggressive disease.
topic	case report small bowel adenocarcinoma comprehensive genomic profiling precision oncology therapeutic options
url	https://www.frontiersin.org/articles/10.3389/fonc.2021.593561/full
work_keys_str_mv	AT miguelcordovadelgado casereportmolecularfeaturesandtreatmentoptionsforsmallboweladenocarcinoma AT miguelcordovadelgado casereportmolecularfeaturesandtreatmentoptionsforsmallboweladenocarcinoma AT gonzalopizarro casereportmolecularfeaturesandtreatmentoptionsforsmallboweladenocarcinoma AT mauricioppinto casereportmolecularfeaturesandtreatmentoptionsforsmallboweladenocarcinoma AT mariaelisaherrera casereportmolecularfeaturesandtreatmentoptionsforsmallboweladenocarcinoma AT mariaelisaherrera casereportmolecularfeaturesandtreatmentoptionsforsmallboweladenocarcinoma AT marcelogarrido casereportmolecularfeaturesandtreatmentoptionsforsmallboweladenocarcinoma
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Case Report: Molecular Features and Treatment Options for Small Bowel Adenocarcinoma

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