Case Report: Molecular Features and Treatment Options for Small Bowel Adenocarcinoma

Case Report: Molecular Features and Treatment Options for Small Bowel Adenocarcinoma

Small bowel adenocarcinoma (SBA) is a rare malignancy characterized by poor prognosis. Recent efforts have sought to elucidate the genetic landscape and the molecular drivers behind this disease. Herein, we report the main molecular alterations in two metastatic (stage IV) SBA patients. Interestingl...

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Bibliographic Details
Main Authors: Miguel Cordova-Delgado, Gonzalo Pizarro, Mauricio P. Pinto, Maria Elisa Herrera, Marcelo Garrido
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Oncology
Subjects:
case report
small bowel adenocarcinoma
comprehensive genomic profiling
precision oncology
therapeutic options
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.593561/full
Description
Summary:Small bowel adenocarcinoma (SBA) is a rare malignancy characterized by poor prognosis. Recent efforts have sought to elucidate the genetic landscape and the molecular drivers behind this disease. Herein, we report the main molecular alterations in two metastatic (stage IV) SBA patients. Interestingly, one of them had gene alterations that affected signaling pathways previously described for SBA. However, a second patient displayed previously unreported alterations in this particular tumor type. Based on these findings we discuss potential treatment options for patients affected by this rare, aggressive disease.
ISSN:2234-943X

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