Early-Stage Staphylococcus aureus Bloodstream Infection Causes Changes in the Concentrations of Lipoproteins and Acute-Phase Proteins and Is Associated with Low Antibody Titers against Bacterial Virulence Factors

Early-Stage Staphylococcus aureus Bloodstream Infection Causes Changes in the Concentrations of Lipoproteins and Acute-Phase Proteins and Is Associated with Low Antibody Titers against Bacterial Virulence Factors

S. aureus sepsis has a high complication and mortality rate. Given the limited therapeutic possibilities, effective prevention strategies, e.g., a vaccine, or the early identification of high-risk patients would be important but are not available. Our study showed an acute-phase response in patients...

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Bibliographic Details
Main Authors: Stephan Michalik, Nandakumar Sundaramoorthy, Annette Murr, Maren Depke, Uwe Völker, Barbara M. Bröker, Hege Vangstein Aamot, Frank Schmidt
Format: Article
Language:English
Published: American Society for Microbiology 2020-01-01
Series:mSystems
Subjects:
dia mass spectrometry
staphylococcus aureus
biomarker
bloodstream infections
immunoproteomics
proteomics
Online Access:https://doi.org/10.1128/mSystems.00632-19

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