Synthetic biology of proteins: tuning GFPs folding and stability with fluoroproline.

Synthetic biology of proteins: tuning GFPs folding and stability with fluoroproline.

Proline residues affect protein folding and stability via cis/trans isomerization of peptide bonds and by the C(gamma)-exo or -endo puckering of their pyrrolidine rings. Peptide bond conformation as well as puckering propensity can be manipulated by proper choice of ring substituents, e.g. C(gamma)-...

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Bibliographic Details
Main Authors:	Thomas Steiner, Petra Hess, Jae Hyun Bae, Birgit Wiltschi, Luis Moroder, Nediljko Budisa
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2008-02-01
Series:	PLoS ONE
Online Access:	http://europepmc.org/articles/PMC2243022?pdf=render

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