Trans-Epithelial Transport, Metabolism and Biological Activity Assessment of the Multi-Target Lupin Peptide LILPKHSDAD (P5) and Its Metabolite LPKHSDAD (P5-Met)

Trans-Epithelial Transport, Metabolism and Biological Activity Assessment of the Multi-Target Lupin Peptide LILPKHSDAD (P5) and Its Metabolite LPKHSDAD (P5-Met)

P5 (LILPKHSDAD) is a hypocholesterolemic peptide from lupin protein with a multi-target activity, since it inhibits both 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCoAR) and proprotein convertase subtilisin/kexin type-9 (PCSK9). This work shows that, during epithelial transport experiments,...

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Bibliographic Details
Main Authors: Carmen Lammi, Gilda Aiello, Carlotta Bollati, Jianqiang Li, Martina Bartolomei, Giulia Ranaldi, Simonetta Ferruzza, Enrico Mario Alessandro Fassi, Giovanni Grazioso, Yula Sambuy, Anna Arnoldi
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Nutrients
Subjects:
Caco-2 cells
food bioactive peptides
LDLR
PCSK9
trans-epithelial transport
Online Access:https://www.mdpi.com/2072-6643/13/3/863

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