Alterations of Dendritic Cells in Sepsis: Featured Role in Immunoparalysis

Alterations of Dendritic Cells in Sepsis: Featured Role in Immunoparalysis

Sepsis, the leading cause of mortality in intensive care unit, is characterized by hyperinflammatory response in the early stage and followed by a period of immunosuppression. This immune disorder is believed to be the potent factor that is tightly associated with high mortality in sepsis. Dendritic...

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Main Authors: Xia Fan, Zheng Liu, He Jin, Jun Yan, Hua-ping Liang
Format: Article
Language:English
Published: Hindawi Limited 2015-01-01
Series:BioMed Research International
Online Access:http://dx.doi.org/10.1155/2015/903720
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spelling doaj-c7363cde302f41e3877ed0a3d90e71ce2020-11-24T23:12:21ZengHindawi LimitedBioMed Research International2314-61332314-61412015-01-01201510.1155/2015/903720903720Alterations of Dendritic Cells in Sepsis: Featured Role in ImmunoparalysisXia Fan0Zheng Liu1He Jin2Jun Yan3Hua-ping Liang4State Key Laboratory of Trauma, Burns and Combined Injury, Research Institute of Surgery, Daping Hospital, The Third Military Medical University, Chongqing 400042, ChinaState Key Laboratory of Trauma, Burns and Combined Injury, Research Institute of Surgery, Daping Hospital, The Third Military Medical University, Chongqing 400042, ChinaState Key Laboratory of Trauma, Burns and Combined Injury, Research Institute of Surgery, Daping Hospital, The Third Military Medical University, Chongqing 400042, ChinaState Key Laboratory of Trauma, Burns and Combined Injury, Research Institute of Surgery, Daping Hospital, The Third Military Medical University, Chongqing 400042, ChinaState Key Laboratory of Trauma, Burns and Combined Injury, Research Institute of Surgery, Daping Hospital, The Third Military Medical University, Chongqing 400042, ChinaSepsis, the leading cause of mortality in intensive care unit, is characterized by hyperinflammatory response in the early stage and followed by a period of immunosuppression. This immune disorder is believed to be the potent factor that is tightly associated with high mortality in sepsis. Dendritic cells (DCs) serve as professional antigen-presenting cells that play a vital role in immune response by activating T lymphocytes. During the progression of sepsis, DCs have been reported to take part in the aberrant immune response and be necessary for survival. Therefore, a better understanding of the DCs pathology will be undoubtedly beneficial for resolving the problems occurring in sepsis. This review discusses effects of sepsis on DCs number and function, including surface molecules expression, cytokines secretion, and T cell activation, and the underlying mechanism as well as some potential therapeutic strategies.http://dx.doi.org/10.1155/2015/903720
collection DOAJ
language English
format Article
sources DOAJ
author Xia Fan
Zheng Liu
He Jin
Jun Yan
Hua-ping Liang
spellingShingle Xia Fan
Zheng Liu
He Jin
Jun Yan
Hua-ping Liang
Alterations of Dendritic Cells in Sepsis: Featured Role in Immunoparalysis
BioMed Research International
author_facet Xia Fan
Zheng Liu
He Jin
Jun Yan
Hua-ping Liang
author_sort Xia Fan
title Alterations of Dendritic Cells in Sepsis: Featured Role in Immunoparalysis
title_short Alterations of Dendritic Cells in Sepsis: Featured Role in Immunoparalysis
title_full Alterations of Dendritic Cells in Sepsis: Featured Role in Immunoparalysis
title_fullStr Alterations of Dendritic Cells in Sepsis: Featured Role in Immunoparalysis
title_full_unstemmed Alterations of Dendritic Cells in Sepsis: Featured Role in Immunoparalysis
title_sort alterations of dendritic cells in sepsis: featured role in immunoparalysis
publisher Hindawi Limited
series BioMed Research International
issn 2314-6133
2314-6141
publishDate 2015-01-01
description Sepsis, the leading cause of mortality in intensive care unit, is characterized by hyperinflammatory response in the early stage and followed by a period of immunosuppression. This immune disorder is believed to be the potent factor that is tightly associated with high mortality in sepsis. Dendritic cells (DCs) serve as professional antigen-presenting cells that play a vital role in immune response by activating T lymphocytes. During the progression of sepsis, DCs have been reported to take part in the aberrant immune response and be necessary for survival. Therefore, a better understanding of the DCs pathology will be undoubtedly beneficial for resolving the problems occurring in sepsis. This review discusses effects of sepsis on DCs number and function, including surface molecules expression, cytokines secretion, and T cell activation, and the underlying mechanism as well as some potential therapeutic strategies.
url http://dx.doi.org/10.1155/2015/903720
work_keys_str_mv AT xiafan alterationsofdendriticcellsinsepsisfeaturedroleinimmunoparalysis
AT zhengliu alterationsofdendriticcellsinsepsisfeaturedroleinimmunoparalysis
AT hejin alterationsofdendriticcellsinsepsisfeaturedroleinimmunoparalysis
AT junyan alterationsofdendriticcellsinsepsisfeaturedroleinimmunoparalysis
AT huapingliang alterationsofdendriticcellsinsepsisfeaturedroleinimmunoparalysis
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