A tale from TGF-β superfamily for thymus ontogeny and function

A tale from TGF-β superfamily for thymus ontogeny and function

Multiple signaling pathways control every aspect of cell behavior, organ formation and tissue homeostasis throughout the lifespan of any individual. This review takes an ontogenetic view focused on the large superfamily of TGF-β/BMP ligands to address thymus morphogenesis and function in T cell diff...

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Bibliographic Details
Main Authors: Arnon Dias Jurberg, Larissa eVasconcelos-Fontes, Vinicius eCotta-de-Almeida
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-09-01
Series:Frontiers in Immunology
Subjects:
BMP
T cell development
Thymus
TGF-β
Thymopoiesis
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00442/full
Description
Summary:Multiple signaling pathways control every aspect of cell behavior, organ formation and tissue homeostasis throughout the lifespan of any individual. This review takes an ontogenetic view focused on the large superfamily of TGF-β/BMP ligands to address thymus morphogenesis and function in T cell differentiation. Recent findings on a role of GDF11 for reversing aging-related phenotypes are also discussed.
ISSN:1664-3224

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