Neural Mechanisms of Reward Prediction Error in Autism Spectrum Disorder
Few studies have explored neural mechanisms of reward learning in ASD despite evidence of behavioral impairments of predictive abilities in ASD. To investigate the neural correlates of reward prediction errors in ASD, 16 adults with ASD and 14 typically developing controls performed a prediction err...
| Main Authors: | , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Hindawi Limited
2019-01-01
|
| Series: | Autism Research and Treatment |
| Online Access: | http://dx.doi.org/10.1155/2019/5469191 |
| id |
doaj-c71ef43fa1894580b97b2f32f498694e |
|---|---|
| record_format |
Article |
| spelling |
doaj-c71ef43fa1894580b97b2f32f498694e2020-11-24T20:50:00ZengHindawi LimitedAutism Research and Treatment2090-19252090-19332019-01-01201910.1155/2019/54691915469191Neural Mechanisms of Reward Prediction Error in Autism Spectrum DisorderMaya G. Mosner0R. Edward McLaurin1Jessica L. Kinard2Shabnam Hakimi3Jacob Parelman4Jasmine S. Shah5Joshua Bizzell6Rachel K. Greene7Paul M. Cernasov8Erin Walsh9Merideth A. Addicott10Tory Eisenlohr-Moul11R. McKell Carter12Gabriel S. Dichter13Department of Psychology and Neuroscience, University of North Carolina-Chapel Hill, Chapel Hill, NC 27514, USADuke-UNC Brain Imaging and Analysis Center, Duke University Medical Center, Durham, NC 27705, USACarolina Institute for Developmental Disabilities, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, Chapel Hill, NC 27510, USACenter for Cognitive Neuroscience, Duke University Medical Center, NC 27705, USADepartment of Psychology and Neuroscience, University of Colorado Boulder, Boulder, CO 80309, USADepartment of Psychology and Neuroscience, University of North Carolina-Chapel Hill, Chapel Hill, NC 27514, USADuke-UNC Brain Imaging and Analysis Center, Duke University Medical Center, Durham, NC 27705, USADepartment of Psychology and Neuroscience, University of North Carolina-Chapel Hill, Chapel Hill, NC 27514, USADepartment of Psychology and Neuroscience, University of North Carolina-Chapel Hill, Chapel Hill, NC 27514, USADepartment of Psychiatry, University of North Carolina-Chapel Hill, Chapel Hill, NC 57514, USACenter for Addiction Research, University of Arkansas for Medical Science, Little Rock, AR 72205, USADepartment of Psychiatry, University of Illinois at Chicago, Neuropsychiatric Institute, Chicago, IL 60612, USADepartment of Psychology and Neuroscience, University of Colorado Boulder, Boulder, CO 80309, USADepartment of Psychology and Neuroscience, University of North Carolina-Chapel Hill, Chapel Hill, NC 27514, USAFew studies have explored neural mechanisms of reward learning in ASD despite evidence of behavioral impairments of predictive abilities in ASD. To investigate the neural correlates of reward prediction errors in ASD, 16 adults with ASD and 14 typically developing controls performed a prediction error task during fMRI scanning. Results revealed greater activation in the ASD group in the left paracingulate gyrus during signed prediction errors and the left insula and right frontal pole during thresholded unsigned prediction errors. Findings support atypical neural processing of reward prediction errors in ASD in frontostriatal regions critical for prediction coding and reward learning. Results provide a neural basis for impairments in reward learning that may contribute to traits common in ASD (e.g., intolerance of unpredictability).http://dx.doi.org/10.1155/2019/5469191 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Maya G. Mosner R. Edward McLaurin Jessica L. Kinard Shabnam Hakimi Jacob Parelman Jasmine S. Shah Joshua Bizzell Rachel K. Greene Paul M. Cernasov Erin Walsh Merideth A. Addicott Tory Eisenlohr-Moul R. McKell Carter Gabriel S. Dichter |
| spellingShingle |
Maya G. Mosner R. Edward McLaurin Jessica L. Kinard Shabnam Hakimi Jacob Parelman Jasmine S. Shah Joshua Bizzell Rachel K. Greene Paul M. Cernasov Erin Walsh Merideth A. Addicott Tory Eisenlohr-Moul R. McKell Carter Gabriel S. Dichter Neural Mechanisms of Reward Prediction Error in Autism Spectrum Disorder Autism Research and Treatment |
| author_facet |
Maya G. Mosner R. Edward McLaurin Jessica L. Kinard Shabnam Hakimi Jacob Parelman Jasmine S. Shah Joshua Bizzell Rachel K. Greene Paul M. Cernasov Erin Walsh Merideth A. Addicott Tory Eisenlohr-Moul R. McKell Carter Gabriel S. Dichter |
| author_sort |
Maya G. Mosner |
| title |
Neural Mechanisms of Reward Prediction Error in Autism Spectrum Disorder |
| title_short |
Neural Mechanisms of Reward Prediction Error in Autism Spectrum Disorder |
| title_full |
Neural Mechanisms of Reward Prediction Error in Autism Spectrum Disorder |
| title_fullStr |
Neural Mechanisms of Reward Prediction Error in Autism Spectrum Disorder |
| title_full_unstemmed |
Neural Mechanisms of Reward Prediction Error in Autism Spectrum Disorder |
| title_sort |
neural mechanisms of reward prediction error in autism spectrum disorder |
| publisher |
Hindawi Limited |
| series |
Autism Research and Treatment |
| issn |
2090-1925 2090-1933 |
| publishDate |
2019-01-01 |
| description |
Few studies have explored neural mechanisms of reward learning in ASD despite evidence of behavioral impairments of predictive abilities in ASD. To investigate the neural correlates of reward prediction errors in ASD, 16 adults with ASD and 14 typically developing controls performed a prediction error task during fMRI scanning. Results revealed greater activation in the ASD group in the left paracingulate gyrus during signed prediction errors and the left insula and right frontal pole during thresholded unsigned prediction errors. Findings support atypical neural processing of reward prediction errors in ASD in frontostriatal regions critical for prediction coding and reward learning. Results provide a neural basis for impairments in reward learning that may contribute to traits common in ASD (e.g., intolerance of unpredictability). |
| url |
http://dx.doi.org/10.1155/2019/5469191 |
| work_keys_str_mv |
AT mayagmosner neuralmechanismsofrewardpredictionerrorinautismspectrumdisorder AT redwardmclaurin neuralmechanismsofrewardpredictionerrorinautismspectrumdisorder AT jessicalkinard neuralmechanismsofrewardpredictionerrorinautismspectrumdisorder AT shabnamhakimi neuralmechanismsofrewardpredictionerrorinautismspectrumdisorder AT jacobparelman neuralmechanismsofrewardpredictionerrorinautismspectrumdisorder AT jasminesshah neuralmechanismsofrewardpredictionerrorinautismspectrumdisorder AT joshuabizzell neuralmechanismsofrewardpredictionerrorinautismspectrumdisorder AT rachelkgreene neuralmechanismsofrewardpredictionerrorinautismspectrumdisorder AT paulmcernasov neuralmechanismsofrewardpredictionerrorinautismspectrumdisorder AT erinwalsh neuralmechanismsofrewardpredictionerrorinautismspectrumdisorder AT meridethaaddicott neuralmechanismsofrewardpredictionerrorinautismspectrumdisorder AT toryeisenlohrmoul neuralmechanismsofrewardpredictionerrorinautismspectrumdisorder AT rmckellcarter neuralmechanismsofrewardpredictionerrorinautismspectrumdisorder AT gabrielsdichter neuralmechanismsofrewardpredictionerrorinautismspectrumdisorder |
| _version_ |
1716805117077880832 |