CXCL13/CXCR5 Axis Predicts Poor Prognosis and Promotes Progression Through PI3K/AKT/mTOR Pathway in Clear Cell Renal Cell Carcinoma

CXCL13/CXCR5 Axis Predicts Poor Prognosis and Promotes Progression Through PI3K/AKT/mTOR Pathway in Clear Cell Renal Cell Carcinoma

The chemokine ligands and their receptors play critical roles in cancer progression and patients outcomes. We found that CXCL13 was significantly upregulated in ccRCC tissues compared with normal tissues in both The Cancer Genome Atlas (TCGA) cohort and a validated cohort of 90 pairs ccRCC tissues....

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Bibliographic Details
Main Authors: Zaosong Zheng, Yuhong Cai, Haicheng Chen, Zhiliang Chen, Dingjun Zhu, Qiyu Zhong, Wenlian Xie
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-01-01
Series:Frontiers in Oncology
Subjects:
CXCL13
CXCR5
ccRCC
diagnosis
prognosis
progression
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2018.00682/full

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