Down-regulation of IGHG1 enhances Protoporphyrin IX accumulation and inhibits hemin biosynthesis in colorectal cancer by suppressing the MEK-FECH axis

Down-regulation of IGHG1 enhances Protoporphyrin IX accumulation and inhibits hemin biosynthesis in colorectal cancer by suppressing the MEK-FECH axis

Immunoglobulin γ-1 heavy chain constant region (IGHG1) is a functional isoform of immunoglobulins and plays an important role in the cytolytic activity of immune effector cells. Dysregulated IGHG1 was implicated in the occurrence and development of various tumors. Protoporphyrin IX (PpIX) is an endo...

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Bibliographic Details
Main Authors: Yang Guangjian, Li Gang, Du Xuemei, Zhou Wenting, Zou Xiaohong, Liu Yuanfu, Lv Hong, Li Zhenjiang
Format: Article
Language:English
Published: De Gruyter 2021-09-01
Series:Open Life Sciences
Subjects:
ighg1
protoporphyrin ix
hemin
colorectal cancer
mek-fech
Online Access:https://doi.org/10.1515/biol-2021-0098

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