Biallelic modification of IL2RG leads to severe combined immunodeficiency in pigs

Biallelic modification of IL2RG leads to severe combined immunodeficiency in pigs

Abstracts Background Pigs with SCID can be a useful model in regenerative medicine, xenotransplantation, and cancer cell transplantation studies. Utilizing genome editing technologies such as CRISPR/Cas9 system allows us to generate genetically engineered pigs at a higher efficiency. In this study,...

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Bibliographic Details
Main Authors: Jung-Taek Kang, Bumrae Cho, Junghyun Ryu, Caitlin Ray, Eun-Jin Lee, Yun-Jin Yun, SunMi Ahn, JinSeok Lee, Dal-Young Ji, Nathaniel Jue, Sherrie Clark-Deener, Kiho Lee, Kwang-Wook Park
Format: Article
Language:English
Published: BMC 2016-11-01
Series:Reproductive Biology and Endocrinology
Subjects:
IL2RG
Severe Combined Immunodeficiency (SCID)
CRISPR/Cas9
Somatic cell nuclear transfer (SCNT)
Knockout pigs
Online Access:http://link.springer.com/article/10.1186/s12958-016-0206-5

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