The HIF-1α antisense long non-coding RNA drives a positive feedback loop of HIF-1α mediated transactivation and glycolysis

The HIF-1α antisense long non-coding RNA drives a positive feedback loop of HIF-1α mediated transactivation and glycolysis

HIF1alpha is reported to drive tumourigenesis through activating glycolysis. Here, the authors show that HIFAL, the HIF1alpha antisense long non-coding RNA, and HIF1alpha form a positive feed-forward loop which is essential for HIF1a-mediated metabolic reprogramming and oncogenic role.

Bibliographic Details
Main Authors: Fang Zheng, Jianing Chen, Xiaoqian Zhang, Zifeng Wang, Jiewen Chen, Xiaorong Lin, Hongyan Huang, Wenkui Fu, Jing Liang, Wei Wu, Bo Li, Herui Yao, Hai Hu, Erwei Song
Format: Article
Language:English
Published: Nature Publishing Group 2021-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-21535-3
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spelling doaj-c702d84ac1fb4ff4b8091efb501878532021-03-11T11:33:01ZengNature Publishing GroupNature Communications2041-17232021-02-0112112010.1038/s41467-021-21535-3The HIF-1α antisense long non-coding RNA drives a positive feedback loop of HIF-1α mediated transactivation and glycolysisFang Zheng0Jianing Chen1Xiaoqian Zhang2Zifeng Wang3Jiewen Chen4Xiaorong Lin5Hongyan Huang6Wenkui Fu7Jing Liang8Wei Wu9Bo Li10Herui Yao11Hai Hu12Erwei Song13Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen UniversityGuangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen UniversityBreast Tumor Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen UniversityState Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Collaborative Innovation Center for Cancer MedicineBreast Tumor Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen UniversityBreast Tumor Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen UniversityChongqing Key Laboratory of Molecular Oncology and Epigenetics, the First Affiliated Hospital of Chongqing Medical UniversityDepartment of Oncology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen UniversityDepartment of Biochemistry and Biophysics, School of Basic Medical Sciences, Peking University Health Science CenterGuangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen UniversityGuangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen UniversityGuangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen UniversityGuangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen UniversityGuangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen UniversityHIF1alpha is reported to drive tumourigenesis through activating glycolysis. Here, the authors show that HIFAL, the HIF1alpha antisense long non-coding RNA, and HIF1alpha form a positive feed-forward loop which is essential for HIF1a-mediated metabolic reprogramming and oncogenic role.https://doi.org/10.1038/s41467-021-21535-3
collection DOAJ
language English
format Article
sources DOAJ
author Fang Zheng
Jianing Chen
Xiaoqian Zhang
Zifeng Wang
Jiewen Chen
Xiaorong Lin
Hongyan Huang
Wenkui Fu
Jing Liang
Wei Wu
Bo Li
Herui Yao
Hai Hu
Erwei Song
spellingShingle Fang Zheng
Jianing Chen
Xiaoqian Zhang
Zifeng Wang
Jiewen Chen
Xiaorong Lin
Hongyan Huang
Wenkui Fu
Jing Liang
Wei Wu
Bo Li
Herui Yao
Hai Hu
Erwei Song
The HIF-1α antisense long non-coding RNA drives a positive feedback loop of HIF-1α mediated transactivation and glycolysis
Nature Communications
author_facet Fang Zheng
Jianing Chen
Xiaoqian Zhang
Zifeng Wang
Jiewen Chen
Xiaorong Lin
Hongyan Huang
Wenkui Fu
Jing Liang
Wei Wu
Bo Li
Herui Yao
Hai Hu
Erwei Song
author_sort Fang Zheng
title The HIF-1α antisense long non-coding RNA drives a positive feedback loop of HIF-1α mediated transactivation and glycolysis
title_short The HIF-1α antisense long non-coding RNA drives a positive feedback loop of HIF-1α mediated transactivation and glycolysis
title_full The HIF-1α antisense long non-coding RNA drives a positive feedback loop of HIF-1α mediated transactivation and glycolysis
title_fullStr The HIF-1α antisense long non-coding RNA drives a positive feedback loop of HIF-1α mediated transactivation and glycolysis
title_full_unstemmed The HIF-1α antisense long non-coding RNA drives a positive feedback loop of HIF-1α mediated transactivation and glycolysis
title_sort hif-1α antisense long non-coding rna drives a positive feedback loop of hif-1α mediated transactivation and glycolysis
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2021-02-01
description HIF1alpha is reported to drive tumourigenesis through activating glycolysis. Here, the authors show that HIFAL, the HIF1alpha antisense long non-coding RNA, and HIF1alpha form a positive feed-forward loop which is essential for HIF1a-mediated metabolic reprogramming and oncogenic role.
url https://doi.org/10.1038/s41467-021-21535-3
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