The HIF-1α antisense long non-coding RNA drives a positive feedback loop of HIF-1α mediated transactivation and glycolysis
HIF1alpha is reported to drive tumourigenesis through activating glycolysis. Here, the authors show that HIFAL, the HIF1alpha antisense long non-coding RNA, and HIF1alpha form a positive feed-forward loop which is essential for HIF1a-mediated metabolic reprogramming and oncogenic role.
Bibliographic Details
| Main Authors: |
Fang Zheng,
Jianing Chen,
Xiaoqian Zhang,
Zifeng Wang,
Jiewen Chen,
Xiaorong Lin,
Hongyan Huang,
Wenkui Fu,
Jing Liang,
Wei Wu,
Bo Li,
Herui Yao,
Hai Hu,
Erwei Song |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Publishing Group
2021-02-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-021-21535-3
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