An improved deep learning method for predicting DNA-binding proteins based on contextual features in amino acid sequences.

As the number of known proteins has expanded, how to accurately identify DNA binding proteins has become a significant biological challenge. At present, various computational methods have been proposed to recognize DNA-binding proteins from only amino acid sequences, such as SVM, DNABP and CNN-RNN....

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Bibliographic Details
Main Authors: Siquan Hu, Ruixiong Ma, Haiou Wang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0225317