Statistics of chromatin organization during cell differentiation revealed by heterogeneous cross-linked polymers

Statistics of chromatin organization during cell differentiation revealed by heterogeneous cross-linked polymers

Chromatin is folded into Topologically Associating domains (TADs), with the organization and folding hierarchy of the TADs being highly dynamic. Here the authors develop a parsimonious randomly cross-linked (RCL) polymer model that maps high frequency encounters present in Hi-C data within and betwe...

Full description

Bibliographic Details
Main Authors: O. Shukron, V. Piras, D. Noordermeer, D. Holcman
Format: Article
Language:English
Published: Nature Publishing Group 2019-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-10402-x
id doaj-c70071dba39f424aa41f561fbf358bb7
record_format Article
spelling doaj-c70071dba39f424aa41f561fbf358bb72021-05-11T11:26:51ZengNature Publishing GroupNature Communications2041-17232019-06-0110111110.1038/s41467-019-10402-xStatistics of chromatin organization during cell differentiation revealed by heterogeneous cross-linked polymersO. Shukron0V. Piras1D. Noordermeer2D. Holcman3Group of data modeling, computational Biology and predictive medicine, Ecole Normale SupérieureChromatin Dynamics Group, Institute for Integrative Biology of the Cell (I2BC), CEA, CNRS, Université Paris-sud, University Paris-SaclayChromatin Dynamics Group, Institute for Integrative Biology of the Cell (I2BC), CEA, CNRS, Université Paris-sud, University Paris-SaclayGroup of data modeling, computational Biology and predictive medicine, Ecole Normale SupérieureChromatin is folded into Topologically Associating domains (TADs), with the organization and folding hierarchy of the TADs being highly dynamic. Here the authors develop a parsimonious randomly cross-linked (RCL) polymer model that maps high frequency encounters present in Hi-C data within and between TADs and reconstruct TADs across cell differentiation, revealing local chromatin re-organization.https://doi.org/10.1038/s41467-019-10402-x
collection DOAJ
language English
format Article
sources DOAJ
author O. Shukron
V. Piras
D. Noordermeer
D. Holcman
spellingShingle O. Shukron
V. Piras
D. Noordermeer
D. Holcman
Statistics of chromatin organization during cell differentiation revealed by heterogeneous cross-linked polymers
Nature Communications
author_facet O. Shukron
V. Piras
D. Noordermeer
D. Holcman
author_sort O. Shukron
title Statistics of chromatin organization during cell differentiation revealed by heterogeneous cross-linked polymers
title_short Statistics of chromatin organization during cell differentiation revealed by heterogeneous cross-linked polymers
title_full Statistics of chromatin organization during cell differentiation revealed by heterogeneous cross-linked polymers
title_fullStr Statistics of chromatin organization during cell differentiation revealed by heterogeneous cross-linked polymers
title_full_unstemmed Statistics of chromatin organization during cell differentiation revealed by heterogeneous cross-linked polymers
title_sort statistics of chromatin organization during cell differentiation revealed by heterogeneous cross-linked polymers
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2019-06-01
description Chromatin is folded into Topologically Associating domains (TADs), with the organization and folding hierarchy of the TADs being highly dynamic. Here the authors develop a parsimonious randomly cross-linked (RCL) polymer model that maps high frequency encounters present in Hi-C data within and between TADs and reconstruct TADs across cell differentiation, revealing local chromatin re-organization.
url https://doi.org/10.1038/s41467-019-10402-x
work_keys_str_mv AT oshukron statisticsofchromatinorganizationduringcelldifferentiationrevealedbyheterogeneouscrosslinkedpolymers
AT vpiras statisticsofchromatinorganizationduringcelldifferentiationrevealedbyheterogeneouscrosslinkedpolymers
AT dnoordermeer statisticsofchromatinorganizationduringcelldifferentiationrevealedbyheterogeneouscrosslinkedpolymers
AT dholcman statisticsofchromatinorganizationduringcelldifferentiationrevealedbyheterogeneouscrosslinkedpolymers
_version_ 1721446567314980864

Similar Items