Withanolides, Extracted from Datura Metel L. Inhibit Keratinocyte Proliferation and Imiquimod-Induced Psoriasis-Like Dermatitis via the STAT3/P38/ERK1/2 Pathway

Withanolides, Extracted from Datura Metel L. Inhibit Keratinocyte Proliferation and Imiquimod-Induced Psoriasis-Like Dermatitis via the STAT3/P38/ERK1/2 Pathway

Psoriasis is an immune-mediated inflammatory dermatosis characterized by epidermal hyperplasia and excessive infiltration of inflammatory cells. Withanolides, extracted from <i>Datura metel</i> L.; are the main effective components for the treatment of psoriasis. However, the precise mec...

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Bibliographic Details
Main Authors: Tingting Li, Zheng Wei, Yanping Sun, Qiuhong Wang, Haixue Kuang
Format: Article
Language:English
Published: MDPI AG 2019-07-01
Series:Molecules
Subjects:
psoriasis
withanolides
<i>Datura metel</i> L.
imiquimod
inflammation
Online Access:https://www.mdpi.com/1420-3049/24/14/2596

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