Association of <it>ALOX5AP</it> gene single nucleotide polymorphisms and cerebral infarction in the Han population of northern China

• Main Authors: Zhang Shuang-yan, Xu Mei-ling, Zhang Cui-e, Qu Zheng-yi, Zhang Bin-bin, Zheng Zu-yan, Zhang Li-ming
• Format: Article
• Language: English
• Published: BMC 2012-07-01
• Series: BMC Medical Genetics
• Subjects: Cerebral infarction; ALOX5AP; FLAP; Han ethnicity; SNP
• Online Access: http://www.biomedcentral.com/1471-2350/13/61

<p>Abstract</p> <p>Background</p> <p>To explore the association of <it>ALOX5AP</it> single nucleotide polymorphisms (SNPs) and haplotype with the occurrence of cerebral infarction in the Han population of northern China.</p> <p>Methods</p> <p>Blood samples were collected from 236 patients of Han ancestry with a history of cerebral infarction and 219 healthy subjects of Han ancestry with no history of cerebral infarction or cardiovascular disease. Applied Biosystems® TaqMan® SNP Genotyping Assays for SNP genotyping were used to determine the genotypes of 7 <it>ALOX5AP</it> SNP alleles (rs4073259, rs4769874, rs9315050, rs9551963, rs10507391, rs9579646, and rs4147064).</p> <p>Results</p> <p>One SNP allele (A) of rs4073259 was significantly associated with development of cerebral infarction (<it>P</it> = 0.049). In comparison to control groups, haplotype rs9315050&rs9551963 AAAC [OR (95% CI) =1.53 (1.02-2.29)], and genotypes rs4147064 CT [OR (95% CI) =1.872 (1.082-3.241)], and rs9551963 AC [OR (95% CI) = 2.015 (1.165-3.484)] increased the risk of cerebral infarction in patients with hypertension. Genotype rs9579646 GG [OR (95% CI) = 2.926 (1.18-7.251)] increased the risk of, while rs4073259 GG [OR (95% CI) = 0.381 (0.157-0.922)] decreased the risk of cerebral infarction in patients with diabetes.</p> <p>Conclusion</p> <p>These results suggest the <it>ALOX5AP</it> SNP A allele in rs4073259 and genotype rs9579646 GG, rs9551963 AC, and haplotype rs9315050 & rs9551963 AAAC were associated with an increased risk of ischemic stroke in the Han population, while rs4073259 GG was associated with a decreased risk.</p>