A short review on sources and health benefits of GLA, The GOOD omega-6

• Main Authors: Van Hoorn René, Kapoor Rakesh, Kamphuis Johan
• Format: Article
• Language: English
• Published: EDP Sciences 2008-07-01
• Series: Oléagineux, Corps gras, Lipides
• Subjects: GLA rich oils; health benefits; omega-6
• Online Access: http://dx.doi.org/10.1051/ocl.2008.0207

GLA rich oils are used mainly for their antiinflammatory effects. As inflammation plays a role in a large number of diseases, GLA can also affect a large number of diseases/conditions. Clinical studies have shown that GLA regulates transepidermal water loss (TEWL), whereby, it prevents dryness and also helps heal eczema and xeroderma. GLA also is shown to stimulate apoptosis of cancer cells without affecting healthy cells. It increases the efficacy of anticancer agents (e.g. tamoxifen) and reduces their side effects by regulating apoptotic gene expression and estrogen receptors. GLA rich oils also reduce the pain and inflammation in rheumatoid arthritis. Recent clinical trial has indicated that GLA can prevent weight regain after weight loss, which is a big concern for people undergoing weight loss. Several human and animal studies have confirmed safety of GLA. The presentation will discuss the various sources for GLA and the actions of GLA in various conditions.