Inhibition of STAT3 blocks protein synthesis and tumor metastasis in osteosarcoma cells

Inhibition of STAT3 blocks protein synthesis and tumor metastasis in osteosarcoma cells

Abstract Background Osteosarcoma is the most common bone cancer. Despite advances, molecular mechanisms associated with osteosarcoma have not been fully understood. Hence, an effective treatment for osteosarcoma has yet to be developed. Even though signal transducer and activator of transcription3 (...

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Bibliographic Details
Main Authors: Dongqing Zuo, Kristen L Shogren, Jie Zang, Donna E Jewison, Brian E Waletzki, Alan L Miller, Scott H Okuno, Zhengdong Cai, Michael J Yaszemski, Avudaiappan Maran
Format: Article
Language:English
Published: BMC 2018-10-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Apoptosis
Napabucasin
Osteosarcoma
Protein synthesis
eIF4E
4EBP-1
Online Access:http://link.springer.com/article/10.1186/s13046-018-0914-0

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