The Structure and Clinical Roles of MicroRNA in Colorectal Cancer

The Structure and Clinical Roles of MicroRNA in Colorectal Cancer

Colorectal cancer (CRC) is one of the most prevalent types of malignancies, particularly among individuals aged between 50 and 75. The global incidence of CRC has been steadily on the rise due in no small part to an aging population and a shift in lifestyle as well as eating habits. MicroRNAs are a...

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Main Authors: Linwensi Zhu, Jingyuan Fang
Format: Article
Language:English
Published: Hindawi Limited 2016-01-01
Series:Gastroenterology Research and Practice
Online Access:http://dx.doi.org/10.1155/2016/1360348
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spelling doaj-c6c6144f5a79491f97138ebf72e517e72020-11-25T00:24:12ZengHindawi LimitedGastroenterology Research and Practice1687-61211687-630X2016-01-01201610.1155/2016/13603481360348The Structure and Clinical Roles of MicroRNA in Colorectal CancerLinwensi Zhu0Jingyuan Fang1Division of Gastroenterology and Hepatology, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health and State Key Laboratory for Oncogenes and Related Genes, Renji Hospital, Shanghai Jiao Tong University, Shanghai Institution of Digestive Disease, 145 Middle Shandong Road, Shanghai 200001, ChinaDivision of Gastroenterology and Hepatology, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health and State Key Laboratory for Oncogenes and Related Genes, Renji Hospital, Shanghai Jiao Tong University, Shanghai Institution of Digestive Disease, 145 Middle Shandong Road, Shanghai 200001, ChinaColorectal cancer (CRC) is one of the most prevalent types of malignancies, particularly among individuals aged between 50 and 75. The global incidence of CRC has been steadily on the rise due in no small part to an aging population and a shift in lifestyle as well as eating habits. MicroRNAs are a group of small, noncoding, and endogenous RNA molecules that have recently emerged as key players in a broad range of pathological pathways. Moreover, dysregulation of microRNAs has been implicated in cancer development and metastasis. This review is intended to provide a brief overview of the structure, functions, and clinical roles of microRNAs. In particular, the review will focus on the discovery, the underlying mechanistic roles, and the diagnostic as well as therapeutic potentials of CRC-specific miRNAs.http://dx.doi.org/10.1155/2016/1360348
collection DOAJ
language English
format Article
sources DOAJ
author Linwensi Zhu
Jingyuan Fang
spellingShingle Linwensi Zhu
Jingyuan Fang
The Structure and Clinical Roles of MicroRNA in Colorectal Cancer
Gastroenterology Research and Practice
author_facet Linwensi Zhu
Jingyuan Fang
author_sort Linwensi Zhu
title The Structure and Clinical Roles of MicroRNA in Colorectal Cancer
title_short The Structure and Clinical Roles of MicroRNA in Colorectal Cancer
title_full The Structure and Clinical Roles of MicroRNA in Colorectal Cancer
title_fullStr The Structure and Clinical Roles of MicroRNA in Colorectal Cancer
title_full_unstemmed The Structure and Clinical Roles of MicroRNA in Colorectal Cancer
title_sort structure and clinical roles of microrna in colorectal cancer
publisher Hindawi Limited
series Gastroenterology Research and Practice
issn 1687-6121
1687-630X
publishDate 2016-01-01
description Colorectal cancer (CRC) is one of the most prevalent types of malignancies, particularly among individuals aged between 50 and 75. The global incidence of CRC has been steadily on the rise due in no small part to an aging population and a shift in lifestyle as well as eating habits. MicroRNAs are a group of small, noncoding, and endogenous RNA molecules that have recently emerged as key players in a broad range of pathological pathways. Moreover, dysregulation of microRNAs has been implicated in cancer development and metastasis. This review is intended to provide a brief overview of the structure, functions, and clinical roles of microRNAs. In particular, the review will focus on the discovery, the underlying mechanistic roles, and the diagnostic as well as therapeutic potentials of CRC-specific miRNAs.
url http://dx.doi.org/10.1155/2016/1360348
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