Improving preimplantation genetic diagnosis (PGD) reliability by selection of sperm donor with the most informative haplotype

Improving preimplantation genetic diagnosis (PGD) reliability by selection of sperm donor with the most informative haplotype

Abstract Background The study is aimed to describe a novel strategy that increases the accuracy and reliability of PGD in patients using sperm donation by pre-selecting the donor whose haplotype does not overlap the carrier’s one. Methods A panel of 4–9 informative polymorphic markers, flanking the...

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Bibliographic Details
Main Authors: Mira Malcov, Veronica Gold, Sagit Peleg, Tsvia Frumkin, Foad Azem, Ami Amit, Dalit Ben-Yosef, Yuval Yaron, Adi Reches, Shimi Barda, Sandra E. Kleiman, Leah Yogev, Ron Hauser
Format: Article
Language:English
Published: BMC 2017-04-01
Series:Reproductive Biology and Endocrinology
Subjects:
PGD
Sperm donor
Polymorphic markers
Haplotype
Online Access:http://link.springer.com/article/10.1186/s12958-017-0247-4

Internet

http://link.springer.com/article/10.1186/s12958-017-0247-4

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