Intermittent Alien Hand Syndrome and Callosal Apraxia in Multiple Sclerosis: Implications for Interhemispheric Communication

Intermittent Alien Hand Syndrome and Callosal Apraxia in Multiple Sclerosis: Implications for Interhemispheric Communication

We report a case of a 47-year-old woman with 35-year history of multiple sclerosis, who showed alien hand signs, a rare behavioural disorder that involves unilateral goal-directed movements that are contrary to the individual's intention. Alien hand syndrome has been described in multiple scler...

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Main Authors: A. Lunardelli, A. Sartori, P. Mengotti, R. I. Rumiati, V. Pesavento
Format: Article
Language:English
Published: Hindawi Limited 2014-01-01
Series:Behavioural Neurology
Online Access:http://dx.doi.org/10.1155/2014/873541
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spelling doaj-c6c3a58171f54ad685598103981dac4f2021-07-02T07:36:37ZengHindawi LimitedBehavioural Neurology0953-41801875-85842014-01-01201410.1155/2014/873541873541Intermittent Alien Hand Syndrome and Callosal Apraxia in Multiple Sclerosis: Implications for Interhemispheric CommunicationA. Lunardelli0A. Sartori1P. Mengotti2R. I. Rumiati3V. Pesavento4Rehabilitation Medicine, Ospedali Riuniti, Trieste, ItalyDepartment of Medical Sciences, University of Trieste, ItalyNeuroscience Area, SISSA, Trieste, ItalyNeuroscience Area, SISSA, Trieste, ItalyRehabilitation Medicine, Ospedali Riuniti, Trieste, ItalyWe report a case of a 47-year-old woman with 35-year history of multiple sclerosis, who showed alien hand signs, a rare behavioural disorder that involves unilateral goal-directed movements that are contrary to the individual's intention. Alien hand syndrome has been described in multiple sclerosis (MS) only occasionally and is generally suggestive of callosal disconnection. The patient presented also with bilateral limb apraxia and left hand agraphia, raising the possibility of cortical dysfunction or disconnection, in addition to corpus callosum and white matter involvement. Her specific pattern of symptoms supports the role of the corpus callosum in interhemispheric communication for complex as well as fine motor activities and may indicate that it can serve as both an inhibitory and excitatory function depending on task demands.http://dx.doi.org/10.1155/2014/873541
collection DOAJ
language English
format Article
sources DOAJ
author A. Lunardelli
A. Sartori
P. Mengotti
R. I. Rumiati
V. Pesavento
spellingShingle A. Lunardelli
A. Sartori
P. Mengotti
R. I. Rumiati
V. Pesavento
Intermittent Alien Hand Syndrome and Callosal Apraxia in Multiple Sclerosis: Implications for Interhemispheric Communication
Behavioural Neurology
author_facet A. Lunardelli
A. Sartori
P. Mengotti
R. I. Rumiati
V. Pesavento
author_sort A. Lunardelli
title Intermittent Alien Hand Syndrome and Callosal Apraxia in Multiple Sclerosis: Implications for Interhemispheric Communication
title_short Intermittent Alien Hand Syndrome and Callosal Apraxia in Multiple Sclerosis: Implications for Interhemispheric Communication
title_full Intermittent Alien Hand Syndrome and Callosal Apraxia in Multiple Sclerosis: Implications for Interhemispheric Communication
title_fullStr Intermittent Alien Hand Syndrome and Callosal Apraxia in Multiple Sclerosis: Implications for Interhemispheric Communication
title_full_unstemmed Intermittent Alien Hand Syndrome and Callosal Apraxia in Multiple Sclerosis: Implications for Interhemispheric Communication
title_sort intermittent alien hand syndrome and callosal apraxia in multiple sclerosis: implications for interhemispheric communication
publisher Hindawi Limited
series Behavioural Neurology
issn 0953-4180
1875-8584
publishDate 2014-01-01
description We report a case of a 47-year-old woman with 35-year history of multiple sclerosis, who showed alien hand signs, a rare behavioural disorder that involves unilateral goal-directed movements that are contrary to the individual's intention. Alien hand syndrome has been described in multiple sclerosis (MS) only occasionally and is generally suggestive of callosal disconnection. The patient presented also with bilateral limb apraxia and left hand agraphia, raising the possibility of cortical dysfunction or disconnection, in addition to corpus callosum and white matter involvement. Her specific pattern of symptoms supports the role of the corpus callosum in interhemispheric communication for complex as well as fine motor activities and may indicate that it can serve as both an inhibitory and excitatory function depending on task demands.
url http://dx.doi.org/10.1155/2014/873541
work_keys_str_mv AT alunardelli intermittentalienhandsyndromeandcallosalapraxiainmultiplesclerosisimplicationsforinterhemisphericcommunication
AT asartori intermittentalienhandsyndromeandcallosalapraxiainmultiplesclerosisimplicationsforinterhemisphericcommunication
AT pmengotti intermittentalienhandsyndromeandcallosalapraxiainmultiplesclerosisimplicationsforinterhemisphericcommunication
AT rirumiati intermittentalienhandsyndromeandcallosalapraxiainmultiplesclerosisimplicationsforinterhemisphericcommunication
AT vpesavento intermittentalienhandsyndromeandcallosalapraxiainmultiplesclerosisimplicationsforinterhemisphericcommunication
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