Transcriptional Up-Regulation of APE1/Ref-1 in Hepatic Tumor: Role in Hepatocytes Resistance to Oxidative Stress and Apoptosis.

Transcriptional Up-Regulation of APE1/Ref-1 in Hepatic Tumor: Role in Hepatocytes Resistance to Oxidative Stress and Apoptosis.

Human Hepatocellular Carcinoma (HCC) is the fifth most frequent neoplasm worldwide and the most serious complication of long-standing chronic liver diseases (CLD). Its development is associated with chronic inflammation and sustained oxidative stress. Deregulation of apurinic apyrimidinic endonuclea...

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Bibliographic Details
Main Authors: Vittorio Di Maso, María Gabriela Mediavilla, Carlo Vascotto, Francesco Lupo, Umberto Baccarani, Claudio Avellini, Gianluca Tell, Claudio Tiribelli, Lory Saveria Crocè
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4666459?pdf=render

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http://europepmc.org/articles/PMC4666459?pdf=render

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