Dissection and function of autoimmunity-associated TNFAIP3 (A20) gene enhancers in humanized mouse models

The human TNFAIP3 gene, which encodes for A20, is associated with autoimmune diseases. Here, the authors use BAC transgenics combined with CRISPR- and recombineering-mediated genome editing to dissect in vivo and in primary immune cells, the role of enhancers regulating TNFAIP3.

Bibliographic Details
Main Authors:	Upneet K. Sokhi, Mark P. Liber, Laura Frye, Sungho Park, Kyuho Kang, Tania Pannellini, Baohong Zhao, Rada Norinsky, Lionel B. Ivashkiv, Shiaoching Gong
Format:	Article
Language:	English
Published:	Nature Publishing Group 2018-02-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-018-03081-7

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spelling	doaj-c6b3ebba7a6c4cca98a75c5a151f33d52021-05-11T10:02:50ZengNature Publishing GroupNature Communications2041-17232018-02-019111510.1038/s41467-018-03081-7Dissection and function of autoimmunity-associated TNFAIP3 (A20) gene enhancers in humanized mouse modelsUpneet K. Sokhi0Mark P. Liber1Laura Frye2Sungho Park3Kyuho Kang4Tania Pannellini5Baohong Zhao6Rada Norinsky7Lionel B. Ivashkiv8Shiaoching Gong9Arthritis and Tissue Degeneration Program, David Z. Rosensweig Center for Genomic Research, Hospital for Special SurgeryArthritis and Tissue Degeneration Program, David Z. Rosensweig Center for Genomic Research, Hospital for Special SurgeryArthritis and Tissue Degeneration Program, David Z. Rosensweig Center for Genomic Research, Hospital for Special SurgeryArthritis and Tissue Degeneration Program, David Z. Rosensweig Center for Genomic Research, Hospital for Special SurgeryArthritis and Tissue Degeneration Program, David Z. Rosensweig Center for Genomic Research, Hospital for Special SurgeryResearch Division and Department of Pathology, Hospital for Special SurgeryArthritis and Tissue Degeneration Program, David Z. Rosensweig Center for Genomic Research, Hospital for Special SurgeryRockefeller UniversityArthritis and Tissue Degeneration Program, David Z. Rosensweig Center for Genomic Research, Hospital for Special SurgeryArthritis and Tissue Degeneration Program, David Z. Rosensweig Center for Genomic Research, Hospital for Special SurgeryThe human TNFAIP3 gene, which encodes for A20, is associated with autoimmune diseases. Here, the authors use BAC transgenics combined with CRISPR- and recombineering-mediated genome editing to dissect in vivo and in primary immune cells, the role of enhancers regulating TNFAIP3.https://doi.org/10.1038/s41467-018-03081-7
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Upneet K. Sokhi Mark P. Liber Laura Frye Sungho Park Kyuho Kang Tania Pannellini Baohong Zhao Rada Norinsky Lionel B. Ivashkiv Shiaoching Gong
spellingShingle	Upneet K. Sokhi Mark P. Liber Laura Frye Sungho Park Kyuho Kang Tania Pannellini Baohong Zhao Rada Norinsky Lionel B. Ivashkiv Shiaoching Gong Dissection and function of autoimmunity-associated TNFAIP3 (A20) gene enhancers in humanized mouse models Nature Communications
author_facet	Upneet K. Sokhi Mark P. Liber Laura Frye Sungho Park Kyuho Kang Tania Pannellini Baohong Zhao Rada Norinsky Lionel B. Ivashkiv Shiaoching Gong
author_sort	Upneet K. Sokhi
title	Dissection and function of autoimmunity-associated TNFAIP3 (A20) gene enhancers in humanized mouse models
title_short	Dissection and function of autoimmunity-associated TNFAIP3 (A20) gene enhancers in humanized mouse models
title_full	Dissection and function of autoimmunity-associated TNFAIP3 (A20) gene enhancers in humanized mouse models
title_fullStr	Dissection and function of autoimmunity-associated TNFAIP3 (A20) gene enhancers in humanized mouse models
title_full_unstemmed	Dissection and function of autoimmunity-associated TNFAIP3 (A20) gene enhancers in humanized mouse models
title_sort	dissection and function of autoimmunity-associated tnfaip3 (a20) gene enhancers in humanized mouse models
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2018-02-01
description	The human TNFAIP3 gene, which encodes for A20, is associated with autoimmune diseases. Here, the authors use BAC transgenics combined with CRISPR- and recombineering-mediated genome editing to dissect in vivo and in primary immune cells, the role of enhancers regulating TNFAIP3.
url	https://doi.org/10.1038/s41467-018-03081-7
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Dissection and function of autoimmunity-associated TNFAIP3 (A20) gene enhancers in humanized mouse models

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