DNA Damage Response Is Involved in the Developmental Toxicity of Mebendazole in Zebrafish Retina

DNA Damage Response Is Involved in the Developmental Toxicity of Mebendazole in Zebrafish Retina

Intestinal helminths cause iron-deficiency anemia in pregnant women, associated with premature delivery, low birth weight, maternal ill health, and maternal death. Although benzimidazole compounds such as mebendazole (MBZ) are highly efficacious against helminths, there are limited data on its use d...

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Bibliographic Details
Main Authors: Yuhei eNishimura, Shota eSasagawa, Tetsuo eKon, Yukiko eYamanaka, Soichiro eMurakami, Yoshifumi eAshikawa, Mizuki eYuge, Shiko eOkabe, Koki eKawaguchi, Reiko eKawase, TOSHIO eTANAKA
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-03-01
Series:Frontiers in Pharmacology
Subjects:
Zebrafish
DNA damage response
Systems toxicology
ATM
developmental toxicity
benzimidazole
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2016.00057/full

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