Characterization and In Vivo Validation of a Three-Dimensional Multi-Cellular Culture Model to Study Heterotypic Interactions in Colorectal Cancer Cell Growth, Invasion and Metastasis

Characterization and In Vivo Validation of a Three-Dimensional Multi-Cellular Culture Model to Study Heterotypic Interactions in Colorectal Cancer Cell Growth, Invasion and Metastasis

Colorectal cancer (CRC) is the third cause of cancer-related mortality in industrialized countries. Local invasion and metastasis formation are events associated with poor prognosis for which today there are no effective therapeutic options. Invasion and metastasis are strongly modulated by cells of...

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Bibliographic Details
Main Authors: Sarah Cattin, Laurent Ramont, Curzio Rüegg
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
colorectal cancer
three-dimensional model (3D)
in vitro
invasion
tumor microenvironment
heterotypic interactions
Online Access:https://www.frontiersin.org/article/10.3389/fbioe.2018.00097/full

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