MicroRNA-424/503 cluster members regulate bovine granulosa cell proliferation and cell cycle progression by targeting SMAD7 gene through activin signalling pathway

MicroRNA-424/503 cluster members regulate bovine granulosa cell proliferation and cell cycle progression by targeting SMAD7 gene through activin signalling pathway

Abstract Background The granulosa cells are indispensable for follicular development and its function is orchestrated by several genes, which in turn posttranscriptionally regulated by microRNAs (miRNA). In our previous study, the miRRNA-424/503 cluster was found to be highly abundant in bovine gran...

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Bibliographic Details
Main Authors: Hari Om Pande, Dawit Tesfaye, Michael Hoelker, Samuel Gebremedhn, Eva Held, Christiane Neuhoff, Ernst Tholen, Karl Schellander, Dessie Salilew Wondim
Format: Article
Language:English
Published: BMC 2018-05-01
Series:Journal of Ovarian Research
Subjects:
miR-424/503 cluster members
Granulosa cells
SMAD7
ACVR2A
Activin a
Online Access:http://link.springer.com/article/10.1186/s13048-018-0410-3

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