Senolytics for Cancer Therapy: Is All That Glitters Really Gold?
Senolytics represent a group of mechanistically diverse drugs that can eliminate senescent cells, both in tumors and in several aging-related pathologies. Consequently, senolytic use has been proposed as a potential adjuvant approach to improve the response to senescence-inducing conventional and ta...
Main Authors: | Valerie J. Carpenter, Tareq Saleh, David A. Gewirtz |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2021-02-01
|
Series: | Cancers |
Subjects: | |
Online Access: | https://www.mdpi.com/2072-6694/13/4/723 |
Similar Items
-
Clearance of therapy‐induced senescent tumor cells by the senolytic ABT‐263 via interference with BCL‐XL–BAX interaction
by: Tareq Saleh, et al.
Published: (2020-10-01) -
An Appraisal on the Value of Using Nutraceutical Based Senolytics and Senostatics in Aging
by: Amanpreet Kaur, et al.
Published: (2020-04-01) -
Senolytics: A Translational Bridge Between Cellular Senescence and Organismal Aging
by: Harikrishnan Thoppil, et al.
Published: (2020-01-01) -
Beyond Tumor Suppression: Senescence in Cancer Stemness and Tumor Dormancy
by: Francisco Triana-Martínez, et al.
Published: (2020-02-01) -
Chemoinformatic Screening for the Selection of Potential Senolytic Compounds from Natural Products
by: Oscar Salvador Barrera-Vázquez, et al.
Published: (2021-03-01)