Calprotectin in rheumatic diseases: a review

• Main Authors: Magdalena Kopeć-Mędrek, Małgorzata Widuchowska, Eugeniusz J. Kucharz
• Format: Article
• Language: English
• Published: Termedia Publishing House 2016-12-01
• Series: Rheumatology
• Subjects: calprotectin; inflammation; inflammatory markers
• Online Access: https://www.termedia.pl/Calprotectin-in-rheumatic-diseases-a-review,18,29026,1,1.html

Calprotectin also known as MRP8/14 or S100A8/A9 is a heterodimeric complex of two S100 calcium-binding proteins: myeloid-related protein 8 (MRP-8 or S100A8) and MRP-14 (or S100A9). At present, according to many authors, it is considered that calprotectin MRP8/14 is a potentially more sensitive biomarker of disease activity in rheumatoid disease than conventional inflammatory indices such as the erythrocyte sedimentation rate, C-reactive protein and others. A review of the literature on concentration of calprotectin in patients with some rheumatic diseases (rheumatoid arthritis, juvenile idiopathic arthritis, adult-onset Still’s disease, systemic vasculitis, polymyalgia rheumatica, ankylosis spondylitis, systemic lupus erythematosus, and primary Sjögren’s syndrome) is presented.