3,7-Dihydroxytropolones Inhibit Initiation of Hepatitis B Virus Minus-Strand DNA Synthesis

3,7-Dihydroxytropolones Inhibit Initiation of Hepatitis B Virus Minus-Strand DNA Synthesis

Initiation of protein-primed (-) strand DNA synthesis in hepatitis B virus (HBV) requires interaction of the viral reverse transcriptase with epsilon (ε), a <i>cis</i>-acting regulatory signal located at the 5’ terminus of pre-genomic RNA (pgRNA), and several host-encoded chaperone prote...

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Bibliographic Details
Main Authors: Ellen Bak, Jennifer T. Miller, Andrea Noronha, John Tavis, Emilio Gallicchio, Ryan P. Murelli, Stuart F. J. Le Grice
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Molecules
Subjects:
Hepatitis B virus
protein priming
epsilon RNA
minus strand DNA synthesis
3,7-dihydroxytropolones
Online Access:https://www.mdpi.com/1420-3049/25/19/4434

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