Treatment Failure in Tuberculosis Patient: The Role of Smoking Habit

• Main Authors: AP Susanto, AA Sani, T Supit, NH Utama, R Andika, TH Arista, F Moegni
• Format: Article
• Language: English
• Published: Universitas Indonesia 2014-04-01
• Series: Journal Kedokteran Indonesia
• Online Access: http://journal.ui.ac.id/index.php/eJKI/article/view/3187

<div>Indonesia faces high burden of Tuberculosis (TB) each year. At the same time, smoking is considered to be common, especially in men. A number of TB patients, who receive standard regimen of TB therapy, would not easily give up on smoking, despite extensive advices from healthcare providers. This report aims to show evidence whether cigarette smoking increases the rate of treatment failure of standard anti-TB regiment in patients with pulmonary TB. Systematic search was done in two databases: Medline and Scopus. Cohort studies were selected as appropriate study design to answer a prognosis question. Two cohort studies are found to be</div><div>relevant with this report. Treatment failures upon standard regimen of TB therapy are 6.9% and &reg; 1.7% in both studies. Smoking habit has been demonstrated to increase the likelihood of treatment &nbsp;failure with OR 2.37 (95% CI: 1.24 &ndash; 4.54) and 7.489 (95% CI: 0.93 &ndash; 60.30). In conclusion,</div><div>treatment failure in standard TB therapy is small. Smoking habit increases the treatment failure of standard anti-TB regiment in patients with pulmonary TB.&nbsp;<br /><br /></div><div><strong>Keywords</strong>: smoking, tuberculosis, treatment failure</div>