TGFβ1 Controls PPARγ Expression, Transcriptional Potential, and Activity, in Part, through Smad3 Signaling in Murine Lung Fibroblasts

TGFβ1 Controls PPARγ Expression, Transcriptional Potential, and Activity, in Part, through Smad3 Signaling in Murine Lung Fibroblasts

Transforming growth factor β1 (TGFβ1) promotes fibrosis by, among other mechanisms, activating quiescent fibroblasts into myofibroblasts and increasing the expression of extracellular matrices. Recent work suggests that peroxisome proliferator-activated receptor γ (PPARγ) is a negative regulator of...

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Bibliographic Details
Main Authors:	Allan Ramirez, Erin N. Ballard, Jesse Roman
Format:	Article
Language:	English
Published:	Hindawi Limited 2012-01-01
Series:	PPAR Research
Online Access:	http://dx.doi.org/10.1155/2012/375876

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