Effect of Normal Saline administration on circulation stability during general anesthesia induction with propofol in gynecological procedures - Randomised-controlled study

• Main Author: Daher Rabadi
• Format: Article
• Language: English
• Published: Elsevier 2013-05-01
• Series: Brazilian Journal of Anesthesiology
• Online Access: http://www.sciencedirect.com/science/article/pii/S010400141300050X

Background and objective: To compare the effect of prophylactic administration of normal saline against the hypotensive effect of propofol in female patients booked for gynecological procedures. Method: Sixty nine ASA (I, II) patients were randomly allocated into two groups, group 1 received 5 mL.kg-1 of 0.9% normal saline 10 minutes before induction, whereas group 2 received nothing (control). Anesthesia was induced with propofol and fentanyl then maintained with propofol and remifentanil. We measured hemodynamic variables pre and post general anesthesia induction. Results: Both groups had significant drops in post induction mean arterial blood pressure (P < 0.001). Also both groups had significant drops in post induction heart rate ((P < 0.02 in sample group and P < 0.001 in control group), and 35% of patients in the control group had more than 25% drop in the pre induction mean arterial blood pressure, compared with only 17% of patients in the saline group (P < 0.04). Conclusion: The prophylactic administration of normal saline could decrease the percentage of patients who had a significant drop in their blood pressure after propofol induction of general anesthesia. Keywords: Isotonic Solutions, Anesthesia, Propofol, Blood Pressure, Heart Rate