Cholinergic Deficit Induced by Central Administration of 192IgG-Saporin Is Associated With Activation of Microglia and Cell Loss in the Dorsal Hippocampus of Rats

Cholinergic Deficit Induced by Central Administration of 192IgG-Saporin Is Associated With Activation of Microglia and Cell Loss in the Dorsal Hippocampus of Rats

Alzheimer’s disease (AD) is associated with degeneration of cholinergic neurons in the basal forebrain. Administration of the immunotoxin 192IgG-saporin to rats, an animal model of AD, leads to degeneration of cholinergic neurons in the medial septal area. In the present study, cholinergic cell deat...

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Bibliographic Details
Main Authors: Yulia V. Dobryakova, Maria N. Volobueva, Anna O. Manolova, Tatiana M. Medvedeva, Alexey A. Kvichansky, Natalia V. Gulyaeva, Vlamidir A. Markevich, Mikhail Yu. Stepanichev, Alexey P. Bolshakov
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Neuroscience
Subjects:
192IgG-saporin
dorsal hippocampus
microglia
vascular endothelium
CA3 area
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2019.00146/full

Internet

https://www.frontiersin.org/article/10.3389/fnins.2019.00146/full

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