Platelet Toll-Like Receptors Mediate Thromboinflammatory Responses in Patients With Essential Thrombocythemia

Platelet Toll-Like Receptors Mediate Thromboinflammatory Responses in Patients With Essential Thrombocythemia

Essential thrombocythemia (ET) is comprised among chronic myeloproliferative neoplasms (MPN) and is caused by driver mutations in JAK2, CALR, and MPL, which lead to megakaryocyte proliferation and prominent thrombocytosis. Thrombosis remains the main cause of morbidity in ET and is driven by the int...

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Bibliographic Details
Main Authors: Cecilia P. Marín Oyarzún, Ana C. Glembotsky, Nora P. Goette, Paola R. Lev, Geraldine De Luca, María C. Baroni Pietto, Beatriz Moiraghi, Miguel A. Castro Ríos, Angeles Vicente, Rosana F. Marta, Mirta Schattner, Paula G. Heller
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Immunology
Subjects:
essential thrombocythemia
platelet immunology
JAK2
thrombosis
inflammation
toll-like receptors
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00705/full

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https://www.frontiersin.org/article/10.3389/fimmu.2020.00705/full

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