Mesendogen, a novel inhibitor of TRPM6, promotes mesoderm and definitive endoderm differentiation of human embryonic stem cells through alteration of magnesium homeostasis

Mesendogen, a novel inhibitor of TRPM6, promotes mesoderm and definitive endoderm differentiation of human embryonic stem cells through alteration of magnesium homeostasis

The homo- and hetero-tetrameric channel complexes formed by transient receptor potential cation channel, subfamily M, member 6 (TRPM6) and 7 (TRPM7) (collectively referred to as TRPM6/TRPM7 channels in this study) are the major regulators of cellular magnesium uptake, yet the exact roles of TRPM6/TR...

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Bibliographic Details
Main Authors:	Yijie Geng, Bradley Feng
Format:	Article
Language:	English
Published:	Elsevier 2015-12-01
Series:	Heliyon
Subjects:	Biological sciences Early embryonic development Stem cells Cell differentiation
Online Access:	http://www.sciencedirect.com/science/article/pii/S2405844015303200

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