Comparison of autophagy inducibility in various tyrosine kinase inhibitors and their enhanced cytotoxicity via inhibition of autophagy in cancer cells in combined treatment with azithromycin

Comparison of autophagy inducibility in various tyrosine kinase inhibitors and their enhanced cytotoxicity via inhibition of autophagy in cancer cells in combined treatment with azithromycin

Tyrosine kinase inhibitors (TKIs) induce autophagy in many types of cancer cells. We previously reported that gefitinib (GEF) and imatinib (IMA) induce autophagy in epidermal growth factor receptor (EGFR) knock-out A549 and non-BCR-ABL-expressing leukemia cell lines, respectively. This evidence sugg...

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Bibliographic Details
Main Authors: Hideki Tanaka, Hirotsugu Hino, Shota Moriya, Hiromi Kazama, Masaya Miyazaki, Naoharu Takano, Masaki Hiramoto, Kiyoaki Tsukahara, Keisuke Miyazawa
Format: Article
Language:English
Published: Elsevier 2020-07-01
Series:Biochemistry and Biophysics Reports
Subjects:
Tyrosine kinase inhibitor
Autophagy
Macrolide antibiotics
Cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2405580820300595

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http://www.sciencedirect.com/science/article/pii/S2405580820300595

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