Modular engineering to increase intracellular NAD(H/+) promotes rate of extracellular electron transfer of Shewanella oneidensis

Modular engineering to increase intracellular NAD(H/+) promotes rate of extracellular electron transfer of Shewanella oneidensis

A bottleneck for the application of bioelectrochemical systems is the slow rate of extracellular electron transfer. Here the authors use a synthetic biology approach to redirect metabolic flux to NAD+ biosynthesis, which enhances the intracellular electron flux and the extracellular electron transfe...

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Main Authors: Feng Li, Yuan-Xiu Li, Ying-Xiu Cao, Lei Wang, Chen-Guang Liu, Liang Shi, Hao Song
Format: Article
Language:English
Published: Nature Publishing Group 2018-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-05995-8
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spelling doaj-c638fd4cd212411a98d2e2f8cb8812842021-05-11T10:24:48ZengNature Publishing GroupNature Communications2041-17232018-09-019111310.1038/s41467-018-05995-8Modular engineering to increase intracellular NAD(H/+) promotes rate of extracellular electron transfer of Shewanella oneidensisFeng Li0Yuan-Xiu Li1Ying-Xiu Cao2Lei Wang3Chen-Guang Liu4Liang Shi5Hao Song6Key Laboratory of Systems Bioengineering (Ministry of Education), SynBio Research Platform, Collaborative Innovation Centre of Chemical Science and Engineering, School of Chemical Engineering and Technology, Tianjin UniversityKey Laboratory of Systems Bioengineering (Ministry of Education), SynBio Research Platform, Collaborative Innovation Centre of Chemical Science and Engineering, School of Chemical Engineering and Technology, Tianjin UniversityKey Laboratory of Systems Bioengineering (Ministry of Education), SynBio Research Platform, Collaborative Innovation Centre of Chemical Science and Engineering, School of Chemical Engineering and Technology, Tianjin UniversityState Key Laboratory of Marine Resource Utilization in South China Sea, College of Information Science & Technology, Hainan UniversityState Key Laboratory of Microbial Metabolism, School of Life Sciences and Biotechnology, Shanghai Jiao Tong UniversityDepartment of Biological Sciences and Technology, School of Environmental Studies, China University of Geoscience in WuhanKey Laboratory of Systems Bioengineering (Ministry of Education), SynBio Research Platform, Collaborative Innovation Centre of Chemical Science and Engineering, School of Chemical Engineering and Technology, Tianjin UniversityA bottleneck for the application of bioelectrochemical systems is the slow rate of extracellular electron transfer. Here the authors use a synthetic biology approach to redirect metabolic flux to NAD+ biosynthesis, which enhances the intracellular electron flux and the extracellular electron transfer rate.https://doi.org/10.1038/s41467-018-05995-8
collection DOAJ
language English
format Article
sources DOAJ
author Feng Li
Yuan-Xiu Li
Ying-Xiu Cao
Lei Wang
Chen-Guang Liu
Liang Shi
Hao Song
spellingShingle Feng Li
Yuan-Xiu Li
Ying-Xiu Cao
Lei Wang
Chen-Guang Liu
Liang Shi
Hao Song
Modular engineering to increase intracellular NAD(H/+) promotes rate of extracellular electron transfer of Shewanella oneidensis
Nature Communications
author_facet Feng Li
Yuan-Xiu Li
Ying-Xiu Cao
Lei Wang
Chen-Guang Liu
Liang Shi
Hao Song
author_sort Feng Li
title Modular engineering to increase intracellular NAD(H/+) promotes rate of extracellular electron transfer of Shewanella oneidensis
title_short Modular engineering to increase intracellular NAD(H/+) promotes rate of extracellular electron transfer of Shewanella oneidensis
title_full Modular engineering to increase intracellular NAD(H/+) promotes rate of extracellular electron transfer of Shewanella oneidensis
title_fullStr Modular engineering to increase intracellular NAD(H/+) promotes rate of extracellular electron transfer of Shewanella oneidensis
title_full_unstemmed Modular engineering to increase intracellular NAD(H/+) promotes rate of extracellular electron transfer of Shewanella oneidensis
title_sort modular engineering to increase intracellular nad(h/+) promotes rate of extracellular electron transfer of shewanella oneidensis
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2018-09-01
description A bottleneck for the application of bioelectrochemical systems is the slow rate of extracellular electron transfer. Here the authors use a synthetic biology approach to redirect metabolic flux to NAD+ biosynthesis, which enhances the intracellular electron flux and the extracellular electron transfer rate.
url https://doi.org/10.1038/s41467-018-05995-8
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AT leiwang modularengineeringtoincreaseintracellularnadhpromotesrateofextracellularelectrontransferofshewanellaoneidensis
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AT liangshi modularengineeringtoincreaseintracellularnadhpromotesrateofextracellularelectrontransferofshewanellaoneidensis
AT haosong modularengineeringtoincreaseintracellularnadhpromotesrateofextracellularelectrontransferofshewanellaoneidensis
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