Activity-mediated accumulation of potassium induces a switch in firing pattern and neuronal excitability type.
During normal neuronal activity, ionic concentration gradients across a neuron's membrane are often assumed to be stable. Prolonged spiking activity, however, can reduce transmembrane gradients and affect voltage dynamics. Based on mathematical modeling, we investigated the impact of neuronal a...
Main Authors: | Susana Andrea Contreras, Jan-Hendrik Schleimer, Allan T Gulledge, Susanne Schreiber |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2021-05-01
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Series: | PLoS Computational Biology |
Online Access: | https://doi.org/10.1371/journal.pcbi.1008510 |
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