CD147 Is a Promising Target of Tumor Progression and a Prognostic Biomarker

Microenvironment plays a crucial role in tumor development and progression. Cancer cells modulate the tumor microenvironment, which also contribute to resistance to therapy. Identifying biomarkers involved in tumorigenesis and cancer progression represents a great challenge for cancer diagnosis and...

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Main Authors:	Alexandra Landras, Coralie Reger de Moura, Fanelie Jouenne, Celeste Lebbe, Suzanne Menashi, Samia Mourah
Format:	Article
Language:	English
Published:	MDPI AG 2019-11-01
Series:	Cancers
Subjects:	cd147 biomarker tumor microenvironment prognosis targeted therapy
Online Access:	https://www.mdpi.com/2072-6694/11/11/1803

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spelling	doaj-c62fe0d34b6442acb2de128271a7af952020-11-25T02:11:59ZengMDPI AGCancers2072-66942019-11-011111180310.3390/cancers11111803cancers11111803CD147 Is a Promising Target of Tumor Progression and a Prognostic BiomarkerAlexandra Landras0Coralie Reger de Moura1Fanelie Jouenne2Celeste Lebbe3Suzanne Menashi4Samia Mourah5INSERM UMRS 976, Team 1, Human Immunology Pathophysiology & Immunotherapy (HIPI), University of Paris, 75010 Paris, FranceINSERM UMRS 976, Team 1, Human Immunology Pathophysiology & Immunotherapy (HIPI), University of Paris, 75010 Paris, FranceINSERM UMRS 976, Team 1, Human Immunology Pathophysiology & Immunotherapy (HIPI), University of Paris, 75010 Paris, FranceINSERM UMRS 976, Team 1, Human Immunology Pathophysiology & Immunotherapy (HIPI), University of Paris, 75010 Paris, FranceINSERM UMRS 976, Team 1, Human Immunology Pathophysiology & Immunotherapy (HIPI), University of Paris, 75010 Paris, FranceINSERM UMRS 976, Team 1, Human Immunology Pathophysiology & Immunotherapy (HIPI), University of Paris, 75010 Paris, FranceMicroenvironment plays a crucial role in tumor development and progression. Cancer cells modulate the tumor microenvironment, which also contribute to resistance to therapy. Identifying biomarkers involved in tumorigenesis and cancer progression represents a great challenge for cancer diagnosis and therapeutic strategy development. CD147 is a glycoprotein involved in the regulation of the tumor microenvironment and cancer progression by several mechanisms—in particular, by the control of glycolysis and also by its well-known ability to induce proteinases leading to matrix degradation, tumor cell invasion, metastasis and angiogenesis. Accumulating evidence has demonstrated the role of CD147 expression in tumor progression and prognosis, suggesting it as a relevant tumor biomarker for cancer diagnosis and prognosis, as well as validating its potential as a promising therapeutic target in cancers.https://www.mdpi.com/2072-6694/11/11/1803cd147biomarkertumor microenvironmentprognosistargeted therapy
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Alexandra Landras Coralie Reger de Moura Fanelie Jouenne Celeste Lebbe Suzanne Menashi Samia Mourah
spellingShingle	Alexandra Landras Coralie Reger de Moura Fanelie Jouenne Celeste Lebbe Suzanne Menashi Samia Mourah CD147 Is a Promising Target of Tumor Progression and a Prognostic Biomarker Cancers cd147 biomarker tumor microenvironment prognosis targeted therapy
author_facet	Alexandra Landras Coralie Reger de Moura Fanelie Jouenne Celeste Lebbe Suzanne Menashi Samia Mourah
author_sort	Alexandra Landras
title	CD147 Is a Promising Target of Tumor Progression and a Prognostic Biomarker
title_short	CD147 Is a Promising Target of Tumor Progression and a Prognostic Biomarker
title_full	CD147 Is a Promising Target of Tumor Progression and a Prognostic Biomarker
title_fullStr	CD147 Is a Promising Target of Tumor Progression and a Prognostic Biomarker
title_full_unstemmed	CD147 Is a Promising Target of Tumor Progression and a Prognostic Biomarker
title_sort	cd147 is a promising target of tumor progression and a prognostic biomarker
publisher	MDPI AG
series	Cancers
issn	2072-6694
publishDate	2019-11-01
description	Microenvironment plays a crucial role in tumor development and progression. Cancer cells modulate the tumor microenvironment, which also contribute to resistance to therapy. Identifying biomarkers involved in tumorigenesis and cancer progression represents a great challenge for cancer diagnosis and therapeutic strategy development. CD147 is a glycoprotein involved in the regulation of the tumor microenvironment and cancer progression by several mechanisms—in particular, by the control of glycolysis and also by its well-known ability to induce proteinases leading to matrix degradation, tumor cell invasion, metastasis and angiogenesis. Accumulating evidence has demonstrated the role of CD147 expression in tumor progression and prognosis, suggesting it as a relevant tumor biomarker for cancer diagnosis and prognosis, as well as validating its potential as a promising therapeutic target in cancers.
topic	cd147 biomarker tumor microenvironment prognosis targeted therapy
url	https://www.mdpi.com/2072-6694/11/11/1803
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CD147 Is a Promising Target of Tumor Progression and a Prognostic Biomarker

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