Counteracting H3K4 methylation modulators Set1 and Jhd2 co-regulate chromatin dynamics and gene transcription

Histone H3K4 methylation affects gene transcription from yeast to humans. Here, the authors show that Set1 and Jhd2, the only H3K4 methyltransferase and H3K4 demethylase, respectively, in budding yeast, co-regulate both positive and negative transcription mediated by nucleosomal turnover and occupan...

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Main Authors:	Saravanan Ramakrishnan, Srijana Pokhrel, Sowmiya Palani, Christian Pflueger, Timothy J. Parnell, Bradley R. Cairns, Srividya Bhaskara, Mahesh B. Chandrasekharan
Format:	Article
Language:	English
Published:	Nature Publishing Group 2016-06-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/ncomms11949

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spelling	doaj-c625e8ba26fc4e15b485691b7990fe442021-05-11T11:05:02ZengNature Publishing GroupNature Communications2041-17232016-06-017111610.1038/ncomms11949Counteracting H3K4 methylation modulators Set1 and Jhd2 co-regulate chromatin dynamics and gene transcriptionSaravanan Ramakrishnan0Srijana Pokhrel1Sowmiya Palani2Christian Pflueger3Timothy J. Parnell4Bradley R. Cairns5Srividya Bhaskara6Mahesh B. Chandrasekharan7Department of Radiation Oncology, University of Utah School of MedicineDepartment of Radiation Oncology, University of Utah School of MedicineDepartment of Radiation Oncology, University of Utah School of MedicineHuntsman Cancer Institute, University of Utah School of MedicineHuntsman Cancer Institute, University of Utah School of MedicineHuntsman Cancer Institute, University of Utah School of MedicineDepartment of Radiation Oncology, University of Utah School of MedicineDepartment of Radiation Oncology, University of Utah School of MedicineHistone H3K4 methylation affects gene transcription from yeast to humans. Here, the authors show that Set1 and Jhd2, the only H3K4 methyltransferase and H3K4 demethylase, respectively, in budding yeast, co-regulate both positive and negative transcription mediated by nucleosomal turnover and occupancy.https://doi.org/10.1038/ncomms11949
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Saravanan Ramakrishnan Srijana Pokhrel Sowmiya Palani Christian Pflueger Timothy J. Parnell Bradley R. Cairns Srividya Bhaskara Mahesh B. Chandrasekharan
spellingShingle	Saravanan Ramakrishnan Srijana Pokhrel Sowmiya Palani Christian Pflueger Timothy J. Parnell Bradley R. Cairns Srividya Bhaskara Mahesh B. Chandrasekharan Counteracting H3K4 methylation modulators Set1 and Jhd2 co-regulate chromatin dynamics and gene transcription Nature Communications
author_facet	Saravanan Ramakrishnan Srijana Pokhrel Sowmiya Palani Christian Pflueger Timothy J. Parnell Bradley R. Cairns Srividya Bhaskara Mahesh B. Chandrasekharan
author_sort	Saravanan Ramakrishnan
title	Counteracting H3K4 methylation modulators Set1 and Jhd2 co-regulate chromatin dynamics and gene transcription
title_short	Counteracting H3K4 methylation modulators Set1 and Jhd2 co-regulate chromatin dynamics and gene transcription
title_full	Counteracting H3K4 methylation modulators Set1 and Jhd2 co-regulate chromatin dynamics and gene transcription
title_fullStr	Counteracting H3K4 methylation modulators Set1 and Jhd2 co-regulate chromatin dynamics and gene transcription
title_full_unstemmed	Counteracting H3K4 methylation modulators Set1 and Jhd2 co-regulate chromatin dynamics and gene transcription
title_sort	counteracting h3k4 methylation modulators set1 and jhd2 co-regulate chromatin dynamics and gene transcription
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2016-06-01
description	Histone H3K4 methylation affects gene transcription from yeast to humans. Here, the authors show that Set1 and Jhd2, the only H3K4 methyltransferase and H3K4 demethylase, respectively, in budding yeast, co-regulate both positive and negative transcription mediated by nucleosomal turnover and occupancy.
url	https://doi.org/10.1038/ncomms11949
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Counteracting H3K4 methylation modulators Set1 and Jhd2 co-regulate chromatin dynamics and gene transcription

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